About fentanyl vs sufentanil vs alfentanil
About fentanyl vs sufentanil vs alfentanil
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Hoehe M, 1988. Influence with the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. Psychoneuroendocrinology
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rifabutin will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, growth of a withdrawal syndrome inside a patient who may have made physical dependence to fentanyl.
levoketoconazole will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Patients with important chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially lowered respiratory reserve, hypoxia, hypercapnia, or pre-current respiratory depression are at greater risk of lessened respiratory travel together with apnea, even at suggested dosages
If coadministration of CYP3A4 inhibitors with fentanyl is critical, keep track of patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose changes till stable drug effects are obtained.
benzhydrocodone/acetaminophen and fentanyl equally enhance sedation. Prevent or Use Alternate Drug. Restrict use to patients for whom option treatment options are inadequate
nalbuphine decreases effects of fentanyl by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics might lower fentanyl's analgesic effect and possibly precipitate withdrawal symptoms.
إعطاء عبر الأدمة، حقن عضلي، حقن وريدي، عبر الفم، إعطاء تحت اللسان، إعطاء شدقي، إعطاء أنفي
If coadministration of fentanyl in urine CYP3A4 inhibitors with fentanyl is important, monitor patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose changes till stable drug effects are reached.
lemborexant, fentanyl. Either improves effects in the other by sedation. Modify Therapy/Watch Closely. Dosage adjustment could be important if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
fentanyl will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may possibly cause higher midazolam systemic exposure, which may prolong sedation.
ferric maltol, fentanyl. Both improves levels on the other by unspecified interaction mechanism. Modify Therapy/Keep track of Intently. Coadministration of ferric maltol with particular oral medications may perhaps lower the bioavailability of possibly ferric maltol and several oral drugs.